It is estimated that 300,000 children 0–14 years of age are diagnosed with cancer worldwide each year. While the absolute risk of cancer in children is low, it is the leading cause of death due to disease in children in high‐income countries. In spite of this, the etiologies of pediatric cancer are largely unknown. Environmental exposures have long been thought to play an etiologic role. However, to date, there are few well‐established environmental risk factors for pediatric malignancies, likely due to (...) technical barriers in collecting biological samples prospectively in pediatric populations for direct measurements. In this review, we propose the use of novel or underutilized biospecimens (dried blood spots and teeth) and molecular approaches for exposure assessment (epigenetics, metabolomics, and somatic mutational profiles). Future epidemiologic studies of pediatric cancer should incorporate novel exposure assessment methodologies, data on molecular features of tumors, and a more complete assessment of gene‐environment interactions. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Arnon Avron has written: “Dunn-McCall logic RM is by far the best understood and the most well-behaved in the family of logics developed by the school of Anderson and Belnap.” I agree. There is the famous saying: “Do not let the perfect become the enemy of the good.” I might say: “good enough.” In this spirit, I will examine the logic R-Mingle, exploring how it is only a “semi-relevant logic” but still a paraconsistent logic. I shall discuss the history of (...) RM, and compare RM to Anderson and Belnap’s system R of relevant implication and to classical two-valued logic. There is a “consumer’s guide,” evaluating these logics as “tools,” in the light of my recent work on “Humans as Rational Toolmaking Animals.”. (shrink)

Résumé Après l’enthousiasme soulevé par le début des années 1990, les peuples autochtones de Sibérie ont dû relever de nombreux défis. Dans le nord-ouest sibérien, au-delà des associations qui militent pour la reconnaissance et les droits autochtones, des expériences individuelles ont vu le jour, qui chacune à leur façon, puisent dans la culture traditionnelle pour s’adapter au cadre complexe de la Fédération de Russie.

First published in 1982, this reissue contains a critical exposition of the views of Frege, Dedekind and Peano on the foundations of arithmetic. The last quarter of the 19th century witnessed a remarkable growth of interest in the foundations of arithmetic. This work analyses both the reasons for this growth of interest within both mathematics and philosophy and the ways in which this study of the foundations of arithmetic led to new insights in philosophy and striking advances in logic. This (...) historical-critical study provides an excellent introduction to the problems of the philosophy of mathematics - problems which have wide implications for philosophy as a whole. This reissue will appeal to students of both mathematics and philosophy who wish to improve their knowledge of logic. (shrink)

The work of Jacques Ellul is useful in understanding and evaluating the implications of rapidly changing technologies for human values and democracy. Ellul developed three powerful theses about technology: technological autonomy, technological determinism, and technological bluff. In this essay, the authors explicate these views of technology, and place the work of Ellul in dialogue with the ides of other important theorists of technology. Ellul’s too-often overlooked theses about technology are relevant to our present technological society.

Impostors, confidence artists, and artful deceivers seem to have achieved a strange kind of popularity and even prestige in our contemporary political landscape, for reasons that remain elusive, especially given how harmful and socially unwanted such behaviors ostensibly are. Herman Melville’s 1857 novel, The Confidence-Man: His Masquerade, helps us shift our perspective on this seemingly irrational phenomenon because it points out how being susceptible to dupery is linked to the enjoyment of fiction itself. This insight also highlights the importance of (...) epistemological failure in the recent “return to aesthetics” in literary studies, where the positive dimension of unconsciously “willing one’s dupery” directly links aesthetic form to politics. The logic that connects aesthetics to unconscious enjoyment is then elaborated in the work of psychoanalytic thinkers such as Sigmund Freud, Jacques Lacan, Helene Deutsch and others to raise particular questions about how and why the enjoyment of being duped has been associated with feminine sexuality. Reading Melville’s novel while considering psychoanalytic concepts such as the “as if” personality, imposture, and interpassivity illuminates how confidence games play upon the ruses of sexuality, which have profound implications for why the public remains in thrall to the workings of known deceivers. (shrink)

Revonsuo proposed an intriguing and detailed evolutionary theory of dreams which stipulates that the biological function of dreaming is to simulate threatening events and to rehearse threat avoidance behaviors. The goal of the present study was to test this theory using a sample of 212 recurrent dreams that was scored using a slightly expanded version of the DreamThreat rating scale. Six of the eight hypotheses tested were supported. Among the positive findings, 66% of the recurrent dream reports contained one or (...) more threats, the threats tended to be dangerous and aimed at the dreamer, and when facing a threat, the dreamer tended to take defensive or evasive actions that were possible and reasonable. However, less than 15% of the recurrent dreams depicted realistic and probable situations critical for one’s physical survival or reproductive success and the dreamer rarely succeeded in fleeing the threat despite important and appropriate efforts. The findings thus provide mixed support for the threat simulation theory. (shrink)

Ce texte est le fruit d’une collaboration entre un astrophysicien, Jean-René Roy, et un philosophe de l’éducation, Normand Baillargeon. Ils ont en commun d’avoir été marqués par la fréquentation des oeuvres de Mario Bunge, auxquelles ils attachent un grand prix, sur un plan personnel, d’abord, mais aussi, et c’est ce qu’ils veulent rappeler dans ces pages : parce qu’ils estiment que les oeuvres de Bunge contribuent de manière extrêmement forte et positive à rendre plus salubre la vie de l’esprit, (...) en enrichissant notre intellect et en luttant contre diverses formes troublantes d’obscurantisme qui y sévissent parfois, notamment dans les domaines familiers aux deux auteurs. (shrink)

Normand Baillargeon, dans ces Légendes pédagogiques, se veut très mordant, virulent parfois, mais toujours juste et honnete dans ce qui se veut une mise en perspective de nos idées reçues sur l'éducation.--[Memento].

Ce texte de Normand Baillargeon part de son expérience de philosophe ayant œuvré dans un département universitaire de sciences de l’éducation au Québec durant plus de 25 ans. Cette expérience parait étayer deux idées que qui méritent d’être portées à l’attention de quiconque se préoccupe de l’état de notre système d’éducation et des débats qu’il suscite. La première de ces idées est que la philosophie de l’éducation est une discipline trop profondément négligée, tant par les philosophes que par les (...) gens œuvrant en sciences de l’éducation et par les décideurs des politiques publiques. La deuxième est que cette négligence peut avoir, et a bien souvent, des conséquences déplorables, voire dramatiques. En espérant avoir à tout le moins convaincu les lecteurs de la plausibilité de ces deux idées, ce texte se termine par la suggestion de quelques pistes d’action susceptibles de corriger cet état de fait. (shrink)

This theory accords to volitions the status of basic mental actions, maintaining that these are spontaneous exercises of the will--a "two-way" power which ...

The ante rem structuralist holds that places in ante rem structures are objects with determinate identity conditions, but he cannot justify this view by providing places with criteria of identity. The latest response to this problem holds that no criteria of identity are required because mathematical practice presupposes a primitive identity relation. This paper criticizes this appeal to mathematical practice. Ante rem structuralism interprets mathematics within the theory of universals, holding that mathematical objects are places in universals. The identity problem (...) should be read as challenging this claim about universals. However, what mathematical practice presupposes is only relevant to what is true according to the theory of universals, if one takes it for granted such a theory offers the best interpretation of mathematics. In the current context, taking this for granted begs the question. Therefore, the appeal to mathematical practice in response to the identity problem is illegitimate. (shrink)

De manière remarquablement constante, la question de l'éducation a été une préoccupation majeure du mouvement anarchiste tout au long de son histoire. Malheureusement, cet héritage demeure en général méconnu, si ce n'est ignoré. Une des ambitions de cette anthologie, qui réunit des textes importants de penseurs et de praticiens anarchistes d'horizons divers, est précisément de nous permettre de redécouvrir la riche tradition dans le domaine de l'éducation de ce courant politico-philosophique. Qu'est-ce que l'éducation? Sur quels plans et pour quelles raisons (...) l'éducation, telle que généralement pratiquée, est-elle déficiente? Comment devrait-on s'y prendre pour former des êtres libres? À ces questions et à de nombreuses autres semblables, des théoriciens ont tenté de répondre, tandis que des praticiens anarchistes se sont efforcés de mettre en oeuvre leur idéal d'une éducation réellement émancipatrice. La présente anthologie, qui comprend deux tomes, réunit les principaux écrits consacrés à l'éducation de ces théoriciens et praticiens anarchistes, des écrits trop peu connus et souvent difficilement accessibles. On retrouve dans ce premier tome, qui couvre les années 1793 à 1918, des textes de Michel Bakounine, Sébastien Faure, Francesco Ferrer, William Godwin, Pierre Kropotkine, Fernand Pelloutier, Pierre-Joseph Proudhon, Paul Robin et Max Stirner. Ils mettent en lumière une riche et toujours inspirante tradition de pensée, de militantisme et de réalisations concrètes. (shrink)

Le present travail propose une analyse philosophique de l'esthetique d'Andre Breton. ;Meme si, en raison de l'importance du surrealisme au XXeme Siecle, cette doctrine semble bien incontournable pour quiconque s'interesse a l'esthetique, elle n'a guere fait, a ce jour, l'objet d'une veritable reflexion philosophique. Notre travail repose donc d'abord sur l'hypothese que l'oeuvre de Breton presente un interet du point de vue philosophique, hypothese qui est etablie en introduction. Faisant ensuite etat des difficultes que rencontre tout examen philosophique du surrealisme, (...) nous precisons le sujet que nous avons retenu compte tenu de ces difficultes: il s'agit de la question de l'art comme manifestation sociale et donc des deux problemes suivants: celui de l'autonomie de l'art, d'une part; celui de l'engagement de l'artiste, d'autre part. ;La suite de notre travail est consacree a une lecture interne des textes de Breton qui permet de cerner le point de vue surrealiste sur ces deux problemes, cette demarche etant menee selon l'approche diachronique que nous avons retenue. Nous sommes parvenus a etablir que Breton croit d'une part en l'autonomie du probleme artistique et d'autre part que l'art authentique est, par la seule vertu de cette authenticite, revolutionnaire et engage. Les corollaires de ces idees sont qu'aucun artiste ne saurait, au risque de nier la signification et la portee de sa demarche propre, ignorer, dans sa discipline, l'etat donne du probleme artistique; que rien ni personne ne saurait dicter a l'art la nature ou la fonction de sa demarche; enfin, que c'est l'art authentique qui fait l'art revolutionnaire et non pas l'art revolutionnaire qui fait l'art authentique. ;Au total, l'oeuvre de Breton promeut une conception revolutionnaire de l'art dont nous avons cherche a degager l'essentiel du point de vue philosophique--option metaphysique moniste d'un univers cryptogrammatique, surrationalisme, surdetermination de l'esthetique par l'ethique--et qui font de son oeuvre une des plus passionnees et des plus convaincantes defense et illustration de l'art au XXeme Siecle. (shrink)

«Les hommes sont hommes avant d'être avocats, médecins, marchands, ou manufacturiers, et si vous en faites des hommes sensés et compétents, ils deviendront par cela même des avocats et des médecins compétents et sensés. [...] On peut être un homme de loi compétent sans avoir reçu une éducation générale; mais il appartient à l'éducation générale de donner à l'homme de loi l'esprit philosophique qui cherche des principes et les saisit, au lieu de charger sa mémoire de détails, et il en (...) va ainsi de toutes les autres professions, y compris les métiers manuels. » John Stuart Mill John Stuart Mill a été nommé en 1865 recteur honoraire de l'Université de St-Andrews. Deux ans plus tard, il y prononce un discours fameux dans lequel il expose ses idées sur l'université et sur l'éducation qu'elle doit procurer à quiconque la fréquente. C'est ce texte qui est ici pour la première fois intégralement présenté aux lecteurs francophones. Ils y mesureront à la fois la distance qui nous sépare de l'université anglaise du XIXe siècle, mais aussi l'actualité des hautes exigences qu'avait le recteur Mill à l'égard de cette institution. Mill reste en effet un réformateur social utilitariste, démocrate et égalitariste, pour qui l'éducation doit former des personnes capables non seulement de développer leurs capacités et dispositions cognitives, émotionnelles et morales de manière à devenir autonomes, mais aussi de coopérer entre eux (et elles) afin de transformer le monde [...] (Normand Baillargeon, Antoine Beaugrand-Champagne et Camille Santerre Baillargeon). (shrink)

Abstract Energy typically is discussed in terms of science, technology, economics, and politics. Little attention has been given to fundamental religious and ethical questions surrounding the upcoming transition to renewable energy. The essays in this thematic section seek to redress that deficiency. This introductory essay raises some key questions and summarizes various presentations on energy and religion, as these were held at the 2010 conference of the Institute on Religion in an Age of Science (IRAS). Some presentations described the energy (...) landscape and provided data and perspectives needed for sound policy. Others raised ethical and religious considerations for energy decisions as the transition from nonrenewable to renewable sources is faced. Some posed the challenges of the energy transition to religion itself. Yet others offered examples of sustainable energy use and/or promising sources for meeting future needs sustainably. At the conclusion of the conference, presenters crafted a common “Statement on Energy and Climate Change” that includes a “Call to Action.” The “Energy Statement” follows as an appendix. (shrink)

Talks 1952 -- Ojai, California 3 August -- August -- August -- Talks 1953 -- Bombay 4 March -- London 9 April -- Ojai, California 4 July -- Talks 1955 -- Amsterdam 26 May -- London 25 June -- Talks 1956 -- Madanapalle, India 26 February -- Brussels 24 June -- June -- Hamburg 6 September -- New Delhi 31 October -- Madras 26 December -- Talks 1957 -- Colombo, Sri Lanka 23 January -- January -- Talks 1958 -- Poona, (...) India 21 September -- Madras 26 October -- November -- Bombay 28 December -- Talks 1959 -- Madras 6 December -- December -- Bombay 23 December. (shrink)

ABSTRACTAnte rem structuralists claim that mathematical objects are places in ante rem structural universals. They also hold that the places in these structural universals instantiate themselves. This paper is an investigation of this self-instantiation thesis. I begin by pointing out that this thesis is of central importance: unless the places of a mathematical structure, such as the places of the natural number structure, themselves instantiate the structure, they cannot have any arithmetical properties. But if places do not have arithmetical properties, (...) then they cannot be the natural numbers. The self-instantiation thesis turns out to be crucial for the identification of mathematical objects with places in structures. Unfortunately, we have no reason to believe that the self-instantiation thesis is true. (shrink)